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Palomba S, de Wilde MA, Falbo A, et al

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Intriguingly, overexpression of LAT4/SLC43A2 in tumor cells enables them to preferentially take up methionine in the tumor microenvironment and deplete methionine in T cells, leading to loss of key epigenetic drivers of cytokine signaling and impaired T cell immunity, while inhibition of LAT4 increased basal and checkpoint-induced tumor immunity [41]